Bottom line
Dentistry.AI was an early entrant in the dental AI imaging space, focused on caries detection from bitewing radiographs. Pearl covers the widest range of dental pathologies in a single FDA-cleared product.
Dentistry.AI or Pearl: which should you choose?
Choose Dentistry.AI if
- Automated caries screening on bitewing radiographs
- Second-opinion caries detection during routine exams
Choose Pearl if
- Multi-condition screening on bitewings and periapicals
- Case acceptance conversations with AI-annotated x-rays
- Practice-wide quality metrics via the analytics dashboard
Dentistry.AI vs Pearl: FDA clearances, price and integrations side by side
| Dentistry.AI | Pearl | |
|---|---|---|
| Vendor | Dentistry.AI Inc · Pompano Beach, FL | Pearl Inc. · Los Angeles, CA |
| Category | Imaging & diagnostics | Imaging & diagnostics |
| FDA 510(k) | None confirmed | K250525 (Nov 14, 2025); K243234 (Jun 12, 2025); K243989 (May 23, 2025); K243230 (May 9, 2025); K243893 (May 5, 2025); K242600 (Apr 11, 2025); K242522 (Jan 16, 2025); K210365 (Mar 4, 2022) |
| Cleared for | — | Marks suspected caries, periapical radiolucency and impacted third molars on panoramic radiographs, patients 16 and older. / Second Opinion CS: detection and segmentation of caries on periapical radiographs, permanent teeth, patients 12 and older (second reader). / Second Opinion 3D: marks anatomy on CBCT (dentition, maxilla, mandible, inferior alveolar canal, sinus, airway). / Second Opinion BLE: bone-level measurements on bitewing and periapical radiographs, patients 12 and older. / Second Opinion Pediatric: caries detection on bitewing and periapical radiographs, patients 4 and older (primary or mixed dentition). / Periapical radiolucency detection with outlined regions on periapical radiographs, permanent teeth, patients 12 and older (second reader). / Second Opinion CC: caries detection with outlined regions on bitewing and periapical radiographs, patients 19 and older (second reader). / Second Opinion: detection of caries, calculus, periapical radiolucency and other findings on bitewing and periapical radiographs. |
| Imaging modalities | bitewing | bitewing, periapical, CBCT |
| Pricing | Not published (Contact sales) | Not published (Contact sales) |
| Integrations | — | Eaglesoft, Dentrix, Open Dental, Curve Dental, Carestack |
| Best fit | — | group, dso |
| Last verified | Oct 21, 2026 | Oct 22, 2026 |
From each vendor's site and the FDA 510(k) database.
Strengths and limits
Dentistry.AI
- Purpose-built for dental caries detection on bitewings
- Software-only architecture meant easier deployment without new hardware
- Company appears inactive; no ongoing product development or support
- No confirmed FDA clearance limits clinical reliance
Pearl
- Detects more pathology types than most competitors in a single analysis
- Widest PMS integration coverage, working with 5+ major systems
- Practice Intelligence adds business analytics on top of clinical detection
- Enterprise pricing model; cost unclear until sales conversation
- Detection accuracy is condition-dependent, strongest on caries, weaker on marginal bone loss
Next steps
Common questions
What is the difference between Dentistry.AI and Pearl?
Dentistry.AI was an early entrant in the dental AI imaging space, focused on caries detection from bitewing radiographs. Pearl covers the widest range of dental pathologies in a single FDA-cleared product.
Which is FDA cleared, Dentistry.AI or Pearl?
Dentistry.AI: no clearance confirmed. Pearl: K250525, K243234, K243989, K243230, K243893, K242600, K242522, K210365. Check the scope of each clearance; features outside it are not cleared.